From 15-18 April, the 2013 Global Newborn Health Conference: Accelerating the Scale-Up of Maternal and Newborn Health Interventions to Reduce Mortality is being held in Johannesburg, South Africa, with a welcome reception and optional supplementary session will be held prior to opening day, on 14 April 2013. Organized by MCHIP, the Bill & Melinda Gates Foundation-supported Save the Children’s Saving Newborn Lives (SC/SNL), and the United Nations Children’s Fund (UNICEF), in collaboration with the World Health Organization (WHO), with additional support from John Snow, Inc., the Laerdal Foundation, and Jhpiego, this four-day meeting will focus on accelerating the scale-up of high-impact interventions that address the three major causes of newborn mortality: prematurity, birth asphyxia and infection.